Factory Price Bulk Supply Pharmaceutical Intermediate Cetirizine Hydrochloride CAS 83881-52-1

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Solid
• Purity: >99%
• Model NO.: 095
• CAS: 83881-52-1
• Grade Standar: Medicine Grade
• Mf: C21h26cl2n2o3
• MW: 425.35
• Transport Package: Bottle, Can, Drum, Plastic Container, Vacuum Packe
• Specification: Powder
• Trademark: Senwayer
• Origin: Wuhan, China
• HS Code: 3001200010
• Production Capacity: 1000kilograms Per Month

Product Description

Factory Price Bulk Supply Pharmaceutical Intermediate Cetirizine Hydrochloride CAS 83881-52-1

Name: Cetirizine hydrochloride
English synonyms: Alercet;Alerid;Cesta;Cetiriz;Cetrak
CAS Number: 83881-52-1
Molecular formula: C21H26Cl2N2O3
Molecular weight: 425.35
EINECS number: 620-533-8

Melting point: 110-115°C
Storage conditions: 2-8°C
Solubility: H2O: soluble5mg/mL, clear
Form: powder
Color: white to beige
Water solubility: Soluble in water and DMSO

Cetirizine is a potent H1 receptor antagonist that enters the body orally and rapidly binds to the histamine H1 receptor on the target cell membrane, blocking histamine from activating target cells. Cetirizine has no significant anticholinergic and anti-serotonin effects. At normal doses, it is not easy to penetrate the blood-brain barrier. This product can inhibit the histamine transmission in the initial stage of allergic reaction, reduce the migration activity of inflammatory cells and the release of transmitters in the late stage of allergic reaction, so it is also effective for allergic reactions in the late stage. This product is a highly selective H1 receptor antagonist, and has not been found to have adverse effects on cardiac electrical activity.

 

Cetirizine is indicated for respiratory, skin and ocular allergic diseases, including perennial allergic diseases such as allergic skin diseases, hives, allergic rhinitis, itchy eyes, conjunctivitis and asthma. This product is also used to treat various types of dermatological allergic diseases. Such as for chronic, artificial, cold, delayed stress, solar measles and atopic dermatitis. This product is also an effective drug for rapid whealing and rapid-onset nucleus and itching caused by mosquito bites.


Cetirizine Hydrochloride is a second-generation H1 antihistamine that is a long-acting, selective oral potent antiallergic drug. H1 receptor antagonists have good anti-allergic reactions and are commonly used in allergic rhinitis, allergic skin itching, conjunctivitis and the like. Compared with its similar drugs such as diphenhydramine, promethazine and chlorpheniramine, cetirizine hydrochloride has a polar polarity and rarely crosses the blood-brain barrier, thus greatly reducing the central sedative effect and selective action. At the H1 receptor, there is little effect on the muscarinic choline receptor and the 5-HT receptor, so there are few side effects associated with anticholinergic activity.