Product Description
Factory supply cas1627580-64-6 Mots-c with fast delivery to your door
| cas |
1627580-64-6 |
| Name |
Mots-c |
| Synonyms |
1627580-64-6 |
| MF |
C101H152N28O22S2 . C2HF3O2 |
| Purity |
99% |
MOTS-c treatment improves physical performance in young mice
We next probed if MOTS-c functions as an exercise-induced mitochondrial signal that improves physical capacity by treating young mice (CD-1; outbred) daily with MOTS-c [5mg/kg/day; intraperitoneal injections (IP)] for 2 weeks; we previously reported that 7 days of MOTS-c treatment improved skeletal muscle insulisensitivity in young and older C57BL/6J mice15. The rotarod performance test, whereby mice are placed on a rotating rod, revealed that daily MOTS-c significantly improved physical capacity and/or motor coordination (Supplementary Fig. 2a), but not grip strength (Supplementary Fig. 2b) in young mice. Because the rotarod test can also be affected by cognitive capacity, we assessed learning and memory using the Barnes maze and found no improvement (Supplementary Fig. 2c, d).
A treadmill running test confirmed that MOTS-c treatment can enhance physical performance. Because MOTS-c is a regulator of metabolic homeostasis that prevented high-fat diet (HFD)-induced obesity and insuli resistance15, we tested if MOTS-c also improved running performance under metabolic (dietary) stress. We fed young mice (CD-1) a HFD (60% calories from fat) and treated them with 2 doses of MOTS-c (5 and 15mg/kg/day; IP; Supplementary Fig. 3a). Mice on the higher dose of MOTS-c showed significantly superior running capacity (Fig. 2a-c) and power output (joules; Supplementary Fig. 4a) following 10 days of treatment, but not following 7 days of treatment (Supplementary Fig. 5a). Notably, 7 days of MOTS-c treatment significantly improved skeletal muscle insuli sensitivity in young and older C57BL/6J mice also fed a high-fat diet15. We progressively increased the treadmill speed to test both endurance and speed. The final stage, which required mice to sprint (23m/min), was reached by 100% of mice on the higher dose of MOTS-c, but only 16.6% in the lower dose and control (vehicle) groups (Fig. 2d). Body composition analysis using a time-domain NMR analyzer revealed that both doses of MOTS-c significantly retarded fat gain and that the high dose significantly increased lean mass in young mice (CD-1; Supplementary Fig. 6a-c), in accord with prior reports15. There was no correlation between body weight and running time (Supplementary Fig. 7a). Taken together, performance improvements in treadmill running and rotarod test, paired with lack of changes in the grip strength and Barnes Maze, indicate an enhancement in physical capacity.
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