Customization: | Available |
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CAS No.: | 1358751-06-0 |
Formula: | C19h23n3o3s |
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Product name | Pyrazino [2,1-C] [1,2,4] Thiadiazine, 9- [4- (Cyclohexyloxy) Phenyl] -3,4-Dihydro-7-METHYL-, 2,2-dioxide |
CAS no. | 1358751-06-0 |
Molecular Formula | C19H23N3O3S |
Molecular Weight | 373.47 |
Brand Name | Senwayer |
Boiling point | 540.8 ± 52.0 ° C (Predict) |
Density | 1.38 ± 0.1 g/cm3 (Predict) |
Acidity coefficient (PKA) | 1.71 ± 0.40 (Predict) |
TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats
Highlights
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TAK-653 stimulated mTOR signaling and BDNF production in primary neurons.
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TAK-653 showed antidepressant-like effects in rat RSBM.
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TAK-653 did not induce hyperlocomotion.
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TAK-653 may be a safer drug for treatment of MDD.
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