| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product name | Eszopiclone |
| CAS number | 138729-47-2 |
| Molecular formula | C17H17ClN6O3 |
| Molecular weight | 388.81 |
| Appearance | White Powder |
| Purity | 99.0% |
| Description | Eszopiclone is a non-benzodiazepine hypnotic agent indicated for the treatment of insomnia to induce sleep and for sleep maintenance. However, unlike its predecessors, eszopiclone is not restricted to short-term treatment of insomnia. Clinical studies of up to 6 months of use show that patients do not develop tolerance to its effect. These agents belong to the cyclopyrrolone class of drugs that act as agonists at the type A GABA receptor. Eszopiclone has approximately 50-fold higher binding affinity than its antipode for GABA-A receptor (IC50=21 and 1130 nM, respectively). In addition, the two enantiomers exhibit significant differences in their pharmacokinetic parameters and in vivo efficacy. In healthy volunteers, eszopiclone has 2-fold higher Cmax and 2-fold greater elimination half-life than the (R)-enantiomer.The two most frequent adverse events associated with eszopiclone treatment are unpleasant taste and headache. Other less frequent side effects include somnolence, dry mouth, and nausea. |
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