Transport Package: | Bottle, Can, Drum, Vial, Plastic Container |
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Specification: | powder |
Trademark: | Senwayer |
Origin: | Wuhan, China |
Samples: |
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Customization: |
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Product name | Kisspeptin 10 (human) |
CAS No. | 374675-21-5 |
MF | C63H83N17O14 |
MW | 1302.44 |
Melting point | N/A |
Boiling point | N/A |
Density | 1.46±0.1 g/cm3(Predicted) |
Storage | -20°C |
Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with K i values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates secretion following i.c.v. administration.
3. Product Effects
Kisspeptin-10 is a stimulator for gonad*otropin-releasing hormone (GnRH). Scientists believe that the exogenous administration of this neuropeptide (naturally secreted by the hypothalamus) can be considered a key regulator of GnRH.
Evidence highlighting the effects of mutations of the KISS1 gene suggests the significant role of Kisspeptin-10 in early or delayed pubertal growth.
Furthermore, Kisspeptin-10 is known to increase LH levels in both men and women. Thus, one can say that Kisspeptin-10 is an LH secretagogue as well.
Although there are several isoforms of human Kisspeptin, KP-10 is the most potent due to its shorter half-life and more rapid onset of its activity after intravenous administration.
Several studies also concluded that Kisspeptin- 10, through the Hypothalamic-pituitary-gonadal axis (HPG axis), can stimulate sexual and emotional brain processing related to olfaction, fear, anxiety, and sexual arousal.
Studies also suggest that Kisspeptin-10 provides a potential link between nutritional status and fertility. It can also increase sex levels in men and sex-related drive.
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