Customization: | Available |
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CAS No.: | 305.33 |
Formula: | C19h14fn2o+ |
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Product name | KP-1 |
CAS no. | 936487-99-9 |
Molecular Formula | C19H14FN2O+ |
Molecular Weight | 305.33 |
Brand Name | Senwayer |
KP1 is a peptide representing the sequence Phe57 to Lys86 of the anti aging protein Klotho, and is one of the buried β-strands in the N-terminal domain. KP1 mimics the anti-fibrotic action of Klotho by constraining TGF-β signaling, KP1 acts through binding to TGF-β receptor 2 (TβR2) and disrupting TGF-β/TβR2 interaction. KP1 inhibits multiple downstream TGF-β pathways including activation of Smad2/3 and mitogen activated protein kinases. In mouse models of renal fibrosis, KP1 preserves kidney function, ameliorates renal fibrosis and restores endogenous Klotho expression.
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