Customization: | Available |
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CAS No.: | 137665-91-9 |
Formula: | C65h90n18o17 |
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Product name | Decapeptide-12 |
CAS No. | 137665-91-9 |
MF | C65H90N18O17 |
MW | 1395.52 |
Melting point | N/A |
Boiling point | N/A |
Density | 1.51±0.1 g/cm3(Predicted) |
Storage | N/A |
Decapeptide-12 is an oligopeptide that is made up of just 12 amino acids. This oligopeptide is known for its anti-tyrosinase activity. Tyrosinase is found in plant and animal tissues and is responsible for catalyzing melanin and other pigments. Decapeptide-12 is being investigated for its possible ability to reduce skin darkening. It's able to interfere with tyrosinase and lighten skin in animal models.
3. Product Mechanism
Decapeptide 12 connects to tyrosinase and prevents it from catalyzing the oxidation of phenols - the initial step in melanin creation.
According to studies, tyrosinase can differ a lot in structure across different species. In mice, differences of tyrosinase determine skin color and are the product of modifications in the TYR gene.
Much research on decapeptide12 centers around its skin lightening effects.
An animal study investigating the safety and efficacy of topical decapeptide-12 in photodamage discovered that the peptide reduced skin pigmentation significantly. The results showed that approximately 40% of test subjects in the study achieved a 100% reduction in hyperpigmentation following 12 weeks.
Meanwhile, 15% of the subjects moved from grade 3 photodamage to grade 1. As for those with grade 4 photodamage (the most severe form), they experienced only slight improvement to grade 3 after the treatment period.
In another study, 100% of mice suffering from melasma saw a drastic change in their skin after decapeptide-12 treatment.
Research shows that decapeptide 12 is around 17 times more powerful than previous treatments for hyperpigmentation.
While the decapeptide 12 studies continue, it is not yet included in commercial skincare products for hyperpigmentation. With more extensive research, decapeptide-12 for sale over the counter should be a possibility.
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