Customization: | Available |
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CAS No.: | 10466-28-1 |
Formula: | C77h108n20o20s |
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Product name | ALPHA-MSH |
CAS No. | 10466-28-1 |
MF | C77H108N20O20S |
MW | 1665.87 |
Storage | −20°C |
Density | 1.48±0.1 g/cm3(Predicted) |
Alpha-Melanocyte Stimulating Hormone (a-MSH) is a subcategory of MSH (there's also beta and gamma MSH).
The two most prominent roles that a-MSH has in human physiology is in causing weight loss (by reducing appetite and increasing energy expenditure) and by increasing tanning.
a-MSH drastically reduces food intake.
a-MSH is a hormone that increases melanocytes, which are skin cells that cause you to become tanned.
Different levels of MSH are not the major cause of racial variation in skin color. However, in many red-headed people, and other people who do not tan well, there are variations in their hormone receptors, causing them to not respond to MSH in the blood.
MSH is an anti-inflammatory hormone and helps build a tolerance to our own and foreign proteins.
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MSH is an anti-inflammatory hormone that also functions as anti-microbial and anti-fungal.
MSH brings down brain inflammation (from TNF).
MSH causes a lower immune response to lectins (PHA).
Receptors responsive to MSH (MCR1) are found on cells of the immune system, which mediates the robust anti-inflammatory properties of a-MSH, which include the prevention of Th1 responses and the induction of T regulatory (TREGS) responses.
MSH improves ni*tric oxide delivery in our blood vessels , which can help with blood flow.
MSH enhances libido, especially in males (through MC3R, MC4R).
In males, it contributes to erections. In females, it contributes to desire and arousal. This is one reason why people with CIRS have a reduced libido.
MSH increases in*sulin sensitivity and lowers blood glucose. It increases glucose uptake by the liver and decreases glucose production from the liver.
MSH reduces abdominal fat and may be the most potent weight reducer.
Leptin reduces weight through the melanocortin system (MC4R) .
Alpha-MSH helps maintain normal levels of aldosterone secretion in animal models.
MSH is also a broad spectrum anti-microbial hormone. Its anti-microbial nature includes anti-fungal properties.
MSH may combat HIV1.
MSH helps in stroke recovery.
Gamma-MSH, which is different but correlated with alpha-MSH, decreases blood pressure.
MSH stimulates the thyroid hormone precursor TRH (precursor to TSH, via MC4R).
Increases in MSH lead to increased T3 in rats.
MSH causes anxiety, which is caused by lowering GABA.
MSH in the amygdala (by activating the MC4R) induces anxiety, inhibits appetite and activates the HPA axis.
MSH stimulates prolactin secretion (through MC3R).
MSH also causes depression.
However, MSH decreases anxiety brought on by inflammation (IL-1b) - presumably by decreasing inflammation.
MSH contributes to opioid tolerance.
MSH increases CRH (precursor to AC*TH/Cortisol).
MSH decreases ADH/Vasopressin in rat studies.