Glucose metabolism Oxyntomodulin Peptide Raw Powder CAS 62340-29-8 OXM
Product name |
Oxyntomodulin |
CAS number |
62340-29-8 |
Molecular formula |
C192H295N59O60S |
Molecular weight |
0 |
Appearance |
White Powder |
Purity |
99.0% |
Packge |
1g,5g,10g or under requirement |
Description |
Oxyntomodulin (OXM) is a peptide hormone released from the gut in post-prandial state that activates both the glucagon-like peptide-1 receptor (GLP1R) and the glucagon receptor (GCGR) resulting in superior body weight lowering to selective GLP1R agonists. OXM reduces food intake and increases energy expenditure in humans. While activation of the GCGR increases glucose production posing a hyperglycemic risk, the simultaneous activation of the GLP1R counteracts this effect. Acute OXM infusion improves glucose tolerance in T2DM patients making dual agonists of the GCGR and GLP1R new promising treatments for diabetes and obesity with the potential for weight loss and glucose lowering superior to that of GLP1R agonists. |
Oxyntomodulin (OXM) is a 37-amino acid peptide hormone secreted from the gut together with GLP-1 following nutrient ingestion. OXM is mainly produced in gut endocrine L-cells by processing of the preproglucagon precursor by prohormone convertase 1/3. While the existence of gut 'glucagon-like substances' was reported in gut extracts since 1948, it was discovered in 1981 that one moiety with 'glucagon-like immunoreactivity' was formed by the sequence of glucagon and a C-terminal octapeptide extension. This moiety was named oxyntomodulin for its ability to modulate gastric acid secretion in gastric oxyntic glands.
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