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Type: | Pharmaceutical Intermediates |
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Quality: | Crude |
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Product name | B-77 |
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B7-33 is a single-chain peptide generated from the larger, naturally occurring protein H2-relaxin that is soluble in water. B7-33 retains relaxin's anti-fibrotic effects without boosting cAMP production. This peptide promotes matrix metalloproteinase 2 (MMP2) production and extracellular collagen breakdown by phosphorylating ERK1/2.
B7-33 is one of several synthetic peptides generated from the human H2-relaxin protein, which is the namesake of the relaxin protein family of four proteins. These closely related proteins have all been found to have pleiotropic effects, affecting the musculoskeletal system, cardiovascular system, and reproduction, among other things.
Endogenous receptors for relaxin family peptides are separated into two pairs (RXFP1/2 and RXFP3/4). The following is a list of the functions of these receptors:
B7-33 is a brand-new peptide having anti-fibrotic properties. It is now being studied and researched as a way to reduce fibrosis in acute and chronic conditions such as heart failure, lung inflammation, and more. In animal tests, B7-33 reduced fibrosis by about 50{bc15fb563bc9e6ea4b4b9214a7065db39a2e1404a7b336cb8ec1271fee783eb0}, allowing for longer survival after injury and providing the first treatment for heart failure in 20 years.
B7-33 may also be used to lessen the foreign body response to medical devices that have been implanted. B7-33 lowers the creation of fibrotic capsules in implanted devices by around 50{bc15fb563bc9e6ea4b4b9214a7065db39a2e1404a7b336cb8ec1271fee783eb0}, the path for new and improved implantable medical devices. B7-33 isn't merely an anti-fibrotic peptide. It also has additional qualities, the most interesting of which is its capacity to lower blood pressure and protect the vasculature.
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