Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product name |
WAY 262611 |
CAS No. |
1123231-07-1 |
Molecular Formula | C20H22N4 |
Molecular Weight | 318.41548 |
Purity | 99% |
Inhibitor of Dickkopf-1 (DKK1);WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 uM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 uM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously.