China Manufacturer 98% CAS 103300-74-9 Peptides Raw Powder Taltirelin
| Name |
Taltirelin |
| English synonyms |
Taltirelin Acetate |
| CAS number |
103300-74-9 |
| Molecular formula |
C17H23N7O5 |
| Molecular weight |
405.41 |
| EINECS number |
- |
| melting point |
72-75° |
| Specific rotation |
25D-13.6°(c=1inwater) |
| density |
1.447±0.06g/cm3(Predicted) |
| Storage conditions |
Store at +4°C |
| Acidity coefficient (pKa) |
9.32±0.40(Predicted) |
Taltirelin is the first approved oral thyrotropin-releasing hormone (TRH) in the world. In addition to endocrine effects, it can also exert certain central nervous system (CNS) effects, including improving motor activity, antagonizing Reserpine-induced hypothermia and antagonism of pentobarbital-induced sleep.
Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant ataxias, are a group of chronic degenerative diseases of the central nervous system with ataxia and dysmetria as the main clinical manifestations. Before September 2000, thyrotropin-releasing hormone (TRH) injection was the only drug used to treat this type of disease.
Tatirelin is a structurally modified drug of TRH. Pharmacological studies have shown that this product has strong and long-lasting multiple effects on the CNS through brain TRH receptors. The excitatory effect of this product on the CNS is 10 to 100 times stronger than that of TRH, and the duration of action is about 8 times longer than that of TRH. The affinity of this product to TRH receptor is about 1/11 of that of TRH, so the endocrine effect of this product is weaker than that of TRH, but this product is more stable than TRH in vivo.
In addition, the effect of this product on the release of thyrotropin (TSH) is 1/6-1/11 of that of TRH. The release of TSH is regulated by a strong negative feedback system including thyroid hormone and has a strong effect on the central nervous system. But at the same time, its hormone-like effect is small, so there are fewer side effects. Adverse reactions were mainly digestive system reactions, including vomiting, nausea and stomach upset. All adverse reactions were mild to moderate and disappeared during treatment and/or after drug withdrawal.
FAQ
Q1:Can i get free sample ?
A: Yes, most product we can send you small free sample, you just need to pay the shipping cost .
Q2:Which payment method you accept?
A: We accept bank transfer,western union, money gram,bitcoin, USDT,Credit card etc. and more bigger order we accept L/C at sight
Q3: Can i get tracking number after shipment ? and how long does the shipping take?
A: After shipment we will offer you tracking and tell you the website to track the package, usually the shipping time is 3-7days,but for some customers have no ability to declare customs, we use special line route to ship the package, it will take 10-12days to arrive,make sure 100% delivery
Q4: How can you guarantee the quality ?
A: All products we can supply you test report &you can also send our product to the third party to do test, if it is fake,we will full refund you.
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