| Customization: | Available |
|---|---|
| Product Name: | P21 |
| CAS No.: | 128-37-0 |
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| Product name | P21 |
| CAS number | 128-37-0 |
| Molecular formula | C15H24O |
| Molecular weight | 220.35 |
| Appearance | White powder |
| Purity | 99.0% |
| Description |
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and thus functions as a regulator of cell cycle progression at G1 and S phase.The binding of p21 to CDK complexes occurs through p21's N-terminal domain, which is homologous to the other CIP/KIP CDK inhibitors p27 and p57. Specifically it contains a Cy1 motif in the N-terminal half, and weaker Cy2 motif in the C-terminal domain that allow it to bind CDK in a region that blocks its ability to complex with cyclins and thus prevent CDK activation.
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