| Customization: | Available |
|---|---|
| CAS No.: | 3054-47-5 |
| Formula: | C12h19n3o7s |
|
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1. Product Basic Information
| Product name | S-ACETYL-L-GLUTATHIONE |
| CAS No. | 3054-47-5 |
| MF | C12H19N3O7S |
| MW | 349.36016 |
| Melting point | N/A |
| Boiling point | 770.2±60.0 °C(Predicted) |
| Density | N/A |
| Storage |
under inert gas (nitrogen) at 2-8 °C
|
3. Product Benefits
S-acetyl- and S-phenyl acetyl-glutathione derivatives were synthesized with the aid of the use of a new process. The results were incubated with rat plasma and red blood cells, and additionally with cytosol from rat liver, kidney, and coronary heart, or tissue slices from rat coronary heart, kidney and liver. Confined hydrolysis of the compounds happens in plasma, whereas hydrolysis occurs to a larger quantity in tissue cytosols. Each purified and crude gamma-glutamyl-transpeptidase from unique assets identified the S-acetyl- and S-phenylacetylene derivatives as substrates. Intracellular glutathione will increase after incubating the products with purple blood cells. An ability role of S-acetyl- and S-phenyl acetyl-glutathione in replenishing cells with exogenous glutathione is envisaged.
Another research studied the impact of decreased glutathione (GSH) and S-acetyl glutathione (S-acglu) remedy on numerous tumor mobile strains, and normal cells in vitro become investigated. GSH and S-acglu were implemented at concentrations of 1 mm, and a pair of mM prompted apoptosis in malignant cells, as shown through DNA-fragmentation and marking of apoptotic cells with 7-amino-actinomycin D while viability and increase of normal cells were now not notably influenced with the aid of this remedy. The outcomes tested that GSH and S-acglu can be selective inducers of apoptosis in malignant cells.
In another study, the glutathione synthetase deficiency, an autosomal recessive inherited metabolic defect inside the gamma-glutamyl cycle, become studied. Decreased intracellular glutathione ranges are one of the characteristic biochemical features. In this observation, we show that the addition of S-acetyl glutathione to the medium raised intracellular glutathione content material in cultured fibroblasts from patients with glutathione synthetase deficiency. This has implications for the treatment of patients with this inborn blunders of metabolism.
4. Product Side Effects
Glutathione is safe for most adults when taken by mouth, through inhalation, or using injection into the muscle or the veins. But the viable aspect outcomes aren't known. For pregnant and breastfeeding individuals, not enough is known about the use of glutathione during pregnancy and breastfeeding. Stay on the safe side and avoid use. And for asthmatic individuals, it must not be inhaled because it can increase some asthma symptom
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