| Customization: | Available |
|---|---|
| CAS No.: | 1146963-51-0 |
| Formula: | C18h17f3n2o2 |
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| cas | 1146963-51-0 |
| Name | J-147 |
| Synonyms | J-147 |
| MF | C18H17F3N2O2 |
| Purity | 99% |
| Application | J-147 is a broad spectrum phenylhydrazin compound with neuroprotective activity (EC50= 60-115nm) |
Mice with rapidly aging brains were treated with CMS121 and J147. The researchers found that it reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. Both compounds preserved mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS121 and J147 increased the levels of acetyl-CoA in cell culture and mice via the inhibition of acetyl-CoA carboxylase 1 (ACC1), resulting in neuroprotection and possible memory enhancement.
Another mouse study found that, by targeting ATP synthase, J147 causes an increase in intracellular calcium leading to sustained calcium/calmodulin-dependent protein kinase β (CAMKK2)-dependent activation of the AM/PK/mTOR pathway, a canonical longevity mechanism.
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