Manufacture Supply Nootropic J 147 Powder J-147 J147 CAS1146963-51-0 with Bulk Price

• CAS No.: 1146963-51-0
• Formula: C18h17f3n2o2
• EINECS: 1146963-51-0
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Technical
• Model NO.: 1146963-51-0
• Colour: White
• Lead Time: 10-15days
• Name: J-147
• Transport Package: 1kg
• Specification: 99%
• Trademark: senwayer
• Origin: China
• Production Capacity: 10000kg/Month

Product Description

    

Product Description

Manufacture Supply Nootropic J 147 Powder J-147 J147 CAS1146963-51-0 with Bulk Price

cas	1146963-51-0
Name	J-147
Synonyms	J-147
MF	C18H17F3N2O2
Purity	99%
Application	J-147 is a broad spectrum phenylhydrazin compound with neuroprotective activity (EC50= 60-115nm)

 

What is J-147 and how does it work?
J-147 is derived from curcumin, the active ingredient in turmeric. Unlike curcumin, it can cross the blood-brain barrier very successfully. J-147 works by binding to ATP synthase. The overproduction of ATP has links to the aging process. J-47 can control this in addition to increasing levels of the neurotransmitters NGF and BDNF. Several studies with J-147 have been conducted in mice. A human trial was carried out in 2020, however, full results have not yet been shared.

J-147 and Dementia

Mice with rapidly aging brains were treated with CMS121 and J147. The researchers found that it reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. Both compounds preserved mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS121 and J147 increased the levels of acetyl-CoA in cell culture and mice via the inhibition of acetyl-CoA carboxylase 1 (ACC1), resulting in neuroprotection and possible memory enhancement. 
Another mouse study found that, by targeting ATP synthase, J147 causes an increase in intracellular calcium leading to sustained calcium/calmodulin-dependent protein kinase β (CAMKK2)-dependent activation of the AM/PK/mTOR pathway, a canonical longevity mechanism.  

Detailed Photos

 

 

Certifications

Packaging & Shipping

Company Profile

Our Advantages

 

FAQ