| Customization: | Available |
|---|---|
| CAS No.: | 1890208-58-8 |
| Formula: | C22h23n3o5s |
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1. Product Basic Information
| Product name | Compound 7P |
| CAS No. | 1890208-58-8 |
| MF | C22H23N3O5S |
| MW | 441.5 |
| Melting point | N/A |
| Boiling point | N/A |
| Density | 1.329±0.06 g/cm3(Predicted) |
| Storage | N/A |
Compound 7p (2-[(2-methoxyphenyl)[(4-methyl phenyl) sulfonyl] amino]-N-(4-methoxy-3-pyridinyl) acetamide) showed the highest activity against cervical cancer cells. In a nude mouse xenograft model inoculated with HeLa cells, 7p showed dose-dependent inhibition of cervical tumour growth. Histopathological examination of excised tumour-bearing tissues showed that 7p improved the microstructure in a dose-dependent manner. Compound 7p also increased the proportions of HeLa cells in G0/G1 and S-phase and significantly decreased that of G2/M-phase. The effects of 7p on C-caspase-3, C-caspase-9, Bcl-2 and Bax expression in HeLa cells were also determined.
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