| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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4′ -Dimethylamino 7, 8-Dihydroxyflavone/4′ -DMA-7, 8-Dhf Hbr Powder CAS 1205548-00-0
What is 7,8-Dihydroxyflavone?
7,8-dihydroxyflavone (7,8-DHF) is a synthetic flavonoid that was initially discovered in a study screening for small molecules that could activate a particular receptor known as tropomyosin-related kinase B (TrkB), because the peptide produced in the human body that acts on this receptor, called brain derived neurotrophic factor (BDNF), could not be used due to poor absorption into the brain. 7,8-DHF was found to be a potent mimic of BDNF able to act on TrkB in a similar manner. This means that 7,8-DHF could theoretically cause similar effects as BDNF in the brain, and in theory be more therapeutically useful due to its better absorption and ability to cross the blood-brain barrier.
Application / dosage:
There are currently no human studies on 7,8-DHF to take human doses from, with all estimates being mathematically approximated from rodent research. The majority of rodent research does use intravenous injections however, with limited studies using oral ingestion.
Oral ingestion does appear to have effects, with rat studies noting:
5mg/kg being effective in the cognitively unwell mouse (chronic usage)
10mg/kg being effective in the cognitively well rat (subchronic use)
30mg/kg in the mouse being acutely effective
This is approximately 1mg/kg for subchronic or chronic usage in humans, with the acute dose correlating to approximately 2.5mg/kg.
In case of any adverse effects, seek medical attention immediately.
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