supplement Nicotinamide adenine dinucleotide powder CAS 53-84-9 NAD NAD+/NADH,NADP+/NADPH/NMN
Physical Characters and specifications
| Product name |
beta-Nicotinamide adenine dinucleotide |
| CAS No. |
53-84-9 |
| Other Names |
NAD |
| Molecular Formula |
C21H27N7O14P2 |
| Molecular weight |
663.43 |
| EINECS NO. |
200-184-4 |
| Grade Standard |
Medicine Grade |
| COA |
Avaliable |
| Item |
Specifications |
| Appearance |
White powder. |
| Purity |
95%, 98%, 99% |
| Melting point |
140 - 142ºC |
| Specific rotation |
D20 -31.5 |
| PH |
~3.0 (50mg/mL in water) |
| Solubility |
H2O: 50 mg/mL |
| Storage condition |
-20ºC |
| Shelf life |
3 years |
Product Introduction
Nicotinamide adenine dinucleotide ( NAD ) is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through theirphosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms: an oxidized and reduced form abbreviated as NAD+ and NADH respectively.
Nicotinamide Adenine Dinucleotide is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II, plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.
In addition, Nicotinamide Adenine Dinucleotide has prevention and treatment of heart block, sinus node function and anti fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.
Function
Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as acoenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. In addition to these metabolic functions, NAD+ emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, and can therefore have important extracellular roles.
The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. Drug design and drug development exploits NAD+ in three ways: as a direct target of drugs, by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by trying to inhibit NAD+biosynthesis.
The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer's and Parkinson disease. Evidence on the benefit of NAD+ in neurodegeneration is mixed; some studies in mice have produced promising results whereas a placebo-controlled clinical trial in humans failed to show any effect.
NAD+ is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by Mycobacterium tuberculosis. Isoniazid is a prodrug and once it has entered the bacteria, it is activated by a peroxidase enzyme, which oxidizes the compound into a free radical form. This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.
1. Nutritional peptides enhance the assimilation of mineral elements.
2. Nucleotides develop nthe immunity and enable animals to produce more IgG and IgM.
3. Nucleotides promote intestinal and bring regeneration of benefical bacteria.
4. Nucleotides accelerate the liver recovery from damages.
5. Mannan oligosaccharides absorb pathogenic bacteria and take them out of bodies.
6. Beta-glucan activate macrophages to improve animal immunity.
7. I+G improve feed palatability and increase the intake
Application
1. Diagnostic reagents raw materials, scientific
research experiments.
2. Health food, cosmetic, feed additive
3. API production
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