Mots-C Peptide

• CAS No.: 1627580-64-6
• Formula: C101h152n28o22s2
• EINECS: N/a
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Crude
• Model NO.: 1627580-64-6
• Colour: White
• Transport Package: Bottle, Can, Drum, Plastic Container
• Specification: Powder
• Trademark: Senwayer
• Origin: Wuhan, China
• HS Code: 3701100000
• Production Capacity: 4000g Per Month

Product Description

1. Product Basic Information

Product name	MOTS-c
CAS No.	1627580-64-6
MF	C101H152N28O22S2
MW	2174.62
Storage	1.44±0.1 g/cm3(Predicted)

2. Product Introduction

MOTS-c is a relatively new peptide of 16 amino acids that promote metabolic balance. It regulates metabolic functions throughout the body. For instance, it turns glucose into usable energy.

The DNA in the cell nucleus encodes most peptides. But, the mitochondria's DNA encodes MOTS-c making it unique among peptides.

Research by the University of Southern California found this peptide may help fight weight gain and normalize metabolism - similar to effects mostly linked with exercise.

In mouse studies, the peptide aided glucose metabolism, even when the mice ate a high-fat diet.

These initial studies could indicate improved blood sugar control for those with obesity and type 2 diabetes.

3. Biological Effects of MOTS-C

• Promotes fatty acid metabolism in the liver
• Promotes metabolic flexibility and homeostasis
• Helps regulate mitochondrial energy
• Protects against age and diet dependent i n s u l i n resistance and obesity
• Helps with weight loss
• Promotes resistance to metabolic stress
• Improves exercise capacity
• Helps prevent osteoporosis
• Improves glucose regulation
• Promotes cell differentiation to form osteoblasts

4. A Dysfunctional Metabolism

In various models of obesity and diabetes we know that some metabolic pathways are dysfunctional. It is caused by competition between sugars, fats and proteins and what we call the 3 prongs of metabolic insensitivity.

1. Distorted nutrient sensing. This means the cell's ability to recognize and respond to substrates such as sugars or fats isn't working. I n s u l i n resistance is an example, it's when cells in your muscles, fat, and liver don't respond well to i n s u l i n and can't use glucose from your blood for energy.
2. Blunted substrate switching. Example: skeletal muscle being unable to switch from carbohydrates to fats for energy needs.
3. Impaired energy homeostasis. The inability of the body to regulate food intake (energy inflow) and energy expenditure (energy outflow).

Excess calories can overwhelm the mitochondria and cause mitochondrial dysfunction.

This has many detrimental effects on metabolism and is strongly associated with weight gain in both humans and animal models.

A Functional Metabolism
A functional metabolism needs proper glucose and i n s u l i n regulation, proper energy consumption and usage and optimal mitochondria functioning. Other factors can contribute as well but the more we learn the more we are understanding that the mitochondria may actively regulate metabolic homeostasis at the cellular level. Could we then propose this equation, fix the mitochondria = fix the metabolism?

How MOTS-c Helps
We know that mitochondria are the main cellular sites devoted to ATP (energy) production and fatty acid oxidation. The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and reduces obesity and i n s u l i n resistance. Mitochondria also play a crucial role in determining metabolic flexibility.