| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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Product Name: Venlafaxine hydrochloride
Synonyms: EFFEXOR;D,L-VENLAFAXINE;D,L-VENLAFAXINE, HYDROCHLORIDE;1-[2-(DIMETHYLAMINO)-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL, HCL;1-[2-(DIMETHYLAMINO)-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL HYDROCHLORIDE;1-[2-(DIMETHYLAMINO)-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL;(+/-)-1-(alpha-((dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride;AKOS 92111
CAS: 99300-78-4
MF: C17H28ClNO2
MW: 313.86
EINECS: 200-659-6
Product Categories: Active Pharmaceutical Ingredients;Medicine intermediate;Antidepressant;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor
mp :207-209°C
storage temp. :Store at RT
Chemical Properties:White Crystalline Powder
Usage:A selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
Description
Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.This means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the body and the brain.
A comparative meta-analysis of 12 major antidepressants found that venlafaxine, mirtazapine, escitalopram, and sertraline were significantly more efficacious than duloxetine, fluoxetine, fluvoxamine, paroxetine, and reboxetine.A combination of venlafaxine and mirtazapine achieved remission rates (defined as a HAM-D score of 7 or less) of 58% in one controlled trial.In combination with an antipsychotic medicine aripiprazole, better results in treatment resistant depression in older adults have been demonstrated.
Usage
Venlafaxine is used primarily for the treatment of depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms.At low doses (<150 mg/day), it acts only on serotonergic transmission. At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission.
Due to its action on both the serotoninergic and adrenergic systems, venlafaxine is also used as a treatment to reduce episodes of cataplexy, a form of muscle weakness, in patients with the sleep disorder narcolepsy.Some open-label and three double-blind studies have suggested the efficacy of venlafaxine in the treatment of attention deficit-hyperactivity disorder (ADHD).Clinical trials have found possible efficacy in those with post-traumatic stress disorder (PTSD).
Certificate of Analysis
| Product Name: | Venlafaxine Hydrochloride (CAS: 99300-78-4) | ||||
| Batch No.: | VH1409003 | Packing Size: | Sample | ||
| Manufacturing Date: | 2015.09.25 | Batch Quantity: | Sample | ||
| Retest Date: | 2015.10.24 | Report Date: | 2015.10.24 | ||
| Quality Standard: | EP7.0 | ||||
| Test Items | Specifications | Results | |||
| Characters | White or almost white powder | Pass | |||
| Identification | A. Consistent with the IR spectrum of the standard | Pass | |||
| B. Chloride reaction | pass | ||||
| Acidity or alkalinity | ≤0.1ml of 0.01 M HCl ≤0.2ml of 0.01 M NaOH |
pass | |||
| Loss on Drying | ≤0.5% (80ºC for 3 hours) | 0.02% | |||
| Sulphated Ash | ≤0.1% | 0.04% | |||
| Heavy Metals | ≤20ppm | <20ppm | |||
| Related Substances | Impurity F ≤0.1% | ND | |||
| Unspecified impurities ≤0.10% | 0.07% | ||||
| Total impurities ≤0.2% | 0.12% | ||||
| Assay | 99.0-101.0%(dried substance) | 99.3% | |||
Our advantage
1,Quality guranteed
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.
2, delivery guranteed
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
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