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Name: Metronidazole
English synonym: 1-Hydroxyethyl-2-methyl-5-nitroimidazole
CAS Number: 443-48-1
Molecular formula: C6H9N3O3
Molecular weight: 171.15
EINECS number: 207-136-1
Metronidazole is an antibiotic that is used commonly to treat protozoal infections and anaerobic bacterial infections. It also has anti-inflammatory effects in the bowel. Metronidazole is bactericidal; it kills bacterial microorganisms by disrupting their DNA. It is absorbed rapidly from the GI tract, metabolized by the liver and excreted in the urine and the feces. Because metronidazole only has activity against anaerobic bacteria, it is used commonly with other antibiotics when it is used to treat mixed-bacterial infections. It is compatible with many other antibiotics including penicillin antibiotics, aminoglycosides, and some cephalosporins.
Metronidazole has strong antibacterial effectto most anaerobic bacteria, used inthetreatment of amebiasis,trichomoniasis and anaerobic infections.
Indications: for the treatment of intestinal and parenteral amebiasis (such as amoebic liver abscess, pleural amebiasis, etc.). but also for the treatment of vaginal trichomoniasis, coccidiosis pouch and cutaneous leishmaniasis, Guinea worm infection. is still widely used in the treatment of anaerobic infections.
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