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Name: Trimethoprim
English synonym: Trimethopim(TMP)
CAS Number: 738-70-5
Molecular formula: C14H18N4O3
Molecular weight: 290.32
EINECS No.: 212-006-2
Melting point: 199-203°C
Boiling point: 432.41°C(rough estimate)
Density: 1.1648(rough estimate)
Refractive index: 1.6000(estimate)
Storage conditions: 2-8°C
Solubility: DMSO: soluble
Acidity coefficient (pKa): 6.6(at25ºC)
Form: white powder
Color: colorless or white
Water solubility: <0.1g/100mLat24ºC
Stability: Stable. Incompatible with strong oxidizing agents, acids.
New oral broad-spectrum antibacterial drugs. The antibacterial spectrum is similar to that of sulfa drugs, but it is more effective and effective against a variety of Gram-positive and negative bacteria. Because bacteria will easily develop resistance to this product, it is not suitable to be used as an antibacterial agent alone. The combined use of trimethoprim and sulfa drugs can increase the antibacterial effect several times to dozens of times. This product is mainly used as a synergist for sulfonamides. It is generally used in a ratio of 1:5. It can also be used as a veterinary medicine to treat sepsis caused by avian coliform bacteria, pullorum, avian typhoid fever, cholera, and secondary bacterial infections of the respiratory system. It can also be used for the treatment of coccidiosis.