Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product name | Palmitoylethanolamide |
CAS number | 544-31-0 |
Molecular formula | C18H37NO2 |
Molecular weight | 299.49 |
Appearance | White powder |
Purity | 99.0% |
Function | Main FunctionPalmitoylethanolamide Anti-Inflammatory and AnalgesicPalmitoylethanolamide Improve the ability ofimmunityPalmitoylethanolamide Treate chronic painPalmitoylethanolamide Treate epilepsy, cerebral ischemia and strokePalmitoylethanolamide Treate Alzheimer's disease and Parkinson's disease PEA has been explored in humans; spanning various clinical trials in a variety of pain states, for inflammatory and pain syndromes. Its positive influence in atopic eczema for instance seems to originate from PPAR alpha activation. PEA is available for human use as a dietary supplement. In a 2012 review, all clinical trials to date were summarized. In a 2015 analysis of a double blind placebo controlled study of PEA in sciatic pain, the Numbers Needed to Treat was 1.5. Its positive influence in chronic pain, and inflammatory states such as atopic eczema, seems to originate mainly from PPAR alpha activation. Since 2012 a number of new trials have been published, among which studies in glaucoma. PEA also seems to be one of the factors responsible for the decrease in pain sensitivity during and after sport, comparable to the endogenous opiates (endorphines). |
Discribe | Palmitoylethanolamide(pea) Powder is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-α). It is an endogenous fattyacid amide, belonging to the class of nuclear factor agonists. PEA is one of themost important endogenous painkilling and anti-inflammatory compounds and has been shown to effective for both acute and chronic pain. Because the substanceacts as a natural painkiller, it is an excellent alternative for conventionalmedications that might cause side effects. |